Three-step scalable production of extracellular vesicles from pancreatic beta cells in stirred tank bioreactors promotes cell maturation and release of ectosomes with preserved immunomodulatory properties
Laurence de Beaurepaire, Thibaud Dauphin, Quentin Pruvost, Apolline Salama, Aurélien Dupont, Laurence Dubreil, Dominique Jégou, Grégoire Mignot, Benjamin Mahieu, Julie Herve, Blandine Lieubeau, Jean‐Marie Bach, Steffi Bösch, Mathilde Mosser
This paper develops a three-step bioprocess using stirred tank bioreactors to produce extracellular vesicles from pancreatic beta cells, enhancing their maturation and immunomodulatory properties.
bioRxiv · Sep 5, 2024 · PreprintBioengineering