Leukemia confers a durable imprint on healthy hematopoietic stem and progenitor cells
Ding-Wen Chen, Julie M. Schrey, Eric K. Wafula, Jian‐Meng Fan, Sarah E. Adams, Deanne M. Taylor, Peter Kurre
This study shows that healthy hematopoietic stem and progenitor cells (HSPCs) retain long-term transcriptomic and epigenetic changes after exposure to acute myeloid leukemia (AML) blasts, leading to enhanced inflammatory and metabolic responses upon secondary challenge.
Cancer Letters · Feb 26, 2025Peer-reviewedCancer Biology