Author

Ding-Wen Chen

Children's Hospital of PhiladelphiaORCID 0000-0003-2806-0307Unclaimed ORCID profile · follow to get notified of new preprints

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Deanne M. TayloriD· 1 shared Eric K. WafulaiD· 1 shared Jian‐Meng Fan· 1 shared Julie M. Schrey· 1 shared Peter KurreiD· 1 shared Sarah E. AdamsiD· 1 shared

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2025-2025 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperCancer Biology

Deanne M. TaylorORCID

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1 paper

Recent·Most cited

Cancer BiologyCancer LettersPeer-reviewedFeb 26, 2025

Leukemia confers a durable imprint on healthy hematopoietic stem and progenitor cells

Ding-Wen Chen, Julie M. Schrey, Eric K. Wafula…·Peter Kurre

This study shows that healthy hematopoietic stem and progenitor cells (HSPCs) retain long-term transcriptomic and epigenetic changes after exposure to acute myeloid leukemia (AML) blasts, leading to enhanced inflammatory and metabolic responses upon secondary challenge.

DOI 10.1016/j.canlet.2025.217590

mousebulk RNA-seq

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