Peter Kurre

This study shows that healthy hematopoietic stem and progenitor cells (HSPCs) retain long-term transcriptomic and epigenetic changes after exposure to acute myeloid leukemia (AML) blasts, leading to enhanced inflammatory and metabolic responses upon secondary challenge.

This paper develops a novel lentiviral vector for gene therapy of MLD that achieves high ARSA activity with minimal genomic integrations, improving safety and efficacy in preclinical models.

The paper develops a method to quantify hematopoietic precursors in mice, showing their contribution to both normal and perturbed hematopoiesis, and applies it to a Fanconi Anemia model.

This study shows FANCD2 reduces replication stress in fetal liver HSC, preventing excessive RPA-coated ssDNA and pChk1 activation.