Genome-wide profiling of an enhancer-associated histone modification reveals the influence of asthma on the epigenome of the airway epithelium.
Peter K. McErlean, Audrey Kelly, Jaideep Dhariwal, Max Kirtland, Julie Watson, Ismael Ranz, David J. Cousins, Roberto C. E. Solari, Michael R. Edwards, Sebastian Lennox Johnston, Paul Lavender
The paper identifies asthma-associated changes in H3K27ac enhancer marks in airway epithelial cells and validates their role in gene expression through CRISPR-based epigenome editing.
bioRxiv · Jun 27, 2019 · PreprintGenomics