Sebastian Lennox Johnston

This study shows human bronchial epithelial cells clear rhinovirus by extruding infected cells in two waves, maintaining barrier integrity but promoting viral transmission.

This study identifies IgG4⁺ plasma cell enrichment and λ-chain-biased BCR remodeling in COPD, linking them to low-grade autoimmunity and chronic inflammation.

This study evaluates a rhinovirus (RV) vaccine, showing it induces cross-reactive T cell immunity and protection against heterotypic RV infection in mice.

This study shows that myocardial injury leads to pulmonary microvascular damage driven by neutrophils and S100A8/A9, which can be reduced by inhibiting S100A8/A9.

The paper identifies asthma-associated changes in H3K27ac enhancer marks in airway epithelial cells and validates their role in gene expression through CRISPR-based epigenome editing.

The paper identifies three distinct immune development trajectories in childhood using unsupervised clustering, revealing a high-risk atopic cluster associated with allergic diseases.

The paper tracks the upper airway microbiome changes in preschool children and links them to asthma-associated persistent wheeze, showing that bacterial shifts precede viral infections and symptoms in sensitized children.