Extrachromosomal DNA micronucleation constrains tumour fitness andimproves patient survival
Lotte Brückner, Robin Xu, Jun Tang, Aditi Gnanasekar, Alexander Herrmann, Ivy Tsz-Lo Wong, Shu Zhang, Fengyu Tu, Madison Pilon, Alexander Kukalev, Katharina Pardon, Olga Alexandra Sidorova, Joshua Atta, Qinghao Yu, Giulia Montouri, , Anton George Henssen
This study shows that ecDNA mis-segregation leads to micronuclei formation, reduced oncogene transcription, and improved patient survival in neuroblastoma.
bioRxiv · Apr 15, 2025 · PreprintCancer Biology