Dynamic optimization of extrachromosomal DNA copy number drives tumour evolution
Aditi Gnanasekar, Shu Zhang, Ellis J. Curtis, Jun Tang, Vishnu Shankar, Ivy Tsz-Lo Wong, Xiaowei Yan, Rui Li, Lu M. Yang, Melissa A. Yao, Andrea Ventura, Benjamin Werner, Howard Y. Chang, Paul S. Mischel
This study shows ecDNA copy number plasticity drives tumour evolution by generating functional heterogeneity and promoting drug resistance.
bioRxiv · Mar 23, 2026 · PreprintCancer Biology