Functional dissection of the conserved C. elegans LEM-3/ANKLE1 nuclease reveals a crucial requirement for the LEM-like and GIY-YIG domains for DNA bridges processing
Junfang Song, Peter Geary, Khadisha Salemova, John Wilson Rouse, Ye Hong, Stéphane G. M. Rolland, Anton Gartner
This study shows that LEM-3/ANKLE1 nuclease cleaves branched DNA substrates and requires both LEM-like and GIY-YIG domains for DNA bridge processing in C. elegans.
Nucleic Acids Research · Mar 20, 2025Peer-reviewedBiochemistry