Systematic over-expression screens for chromosome instability identify conserved dosage chromosome instability genes in yeast and human tumors
Supipi Duffy, Hok Khim Fam, Yikan Wang, Erin B Styles, Jung-Huyn Kim, J. Sidney Ang, Tejomayee Singh, Vladimir Larionov, Sohrab Shah, Brenda Andrews, Cornelius Boerkoel, Phillip Hieter
The paper identifies conserved genes involved in chromosome instability through over-expression screens in yeast and human cells, highlighting Tdp1 and Taf12 as potential therapeutic targets.
bioRxiv · Feb 3, 2016Genetics