Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation
Da-ha Park, So-Young Ahn, Jungho Kim, Jiwoo Choi, Seungha Lee, Minji Kang, Jae‐man Song, Young Ho Suh
This study shows that NMDAR activation triggers calpain 1-mediated cleavage of G3BP1, leading to disassembly of RNP granules and mTOR-dependent local translation, which supports axonal regeneration.
EMBO Reports · Apr 4, 2026Peer-reviewedNeuroscience