Young Ho Suh

This study identifies ATB1071, a compound that activates p62-mediated mitophagy through Arg/N-degrons, showing therapeutic benefits in mitochondrial neuropathies and ischemia-reperfusion injury.

This study shows that NMDAR activation triggers calpain 1-mediated cleavage of G3BP1, leading to disassembly of RNP granules and mTOR-dependent local translation, which supports axonal regeneration.

This study investigates the role of disulfide bonds in the GluN1 subunit of NMDA receptors, showing their impact on trafficking and function, and introduces a method for synchronized release of NMDARs from the endoplasmic reticulum.

This paper demonstrates that AUTOTAC, a targeted degradation approach, reduces tau aggregates and improves symptoms in tauopathy models and companion dogs.

This paper develops AUTOTAC degraders to target and degrade pathogenic TDP-43 aggregates in ALS, showing efficacy in mice and entering clinical trials.

This study identifies Kv4.1 as a key ion channel regulating low-frequency firing in mature dentate granule cells, essential for pattern separation.

This study identifies Nedd4 and beta-arrestins as regulators of mGlu7 ubiquitination, trafficking, and degradation in neurons.