Da-ha Park

Chemical N-degrons activate p62-mediated mitophagy to alleviate mitochondrial neuropathies

This study identifies ATB1071, a compound that activates p62-mediated mitophagy through Arg/N-degrons, showing therapeutic benefits in mitochondrial neuropathies and ischemia-reperfusion injury.

Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation

This study shows that NMDAR activation triggers calpain 1-mediated cleavage of G3BP1, leading to disassembly of RNP granules and mTOR-dependent local translation, which supports axonal regeneration.

Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy

This paper demonstrates that AUTOTAC, a targeted degradation approach, reduces tau aggregates and improves symptoms in tauopathy models and companion dogs.

Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform

This paper develops AUTOTAC degraders to target and degrade pathogenic TDP-43 aggregates in ALS, showing efficacy in mice and entering clinical trials.