Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction
Ashley L. Comer, Tushare Jinadasa, Balaji Sriram, Rhushikesh A. Phadke, Lisa N. Kretsge, Thanh P. H. Nguyen, Giovanna Antognetti, James P. Gilbert, Jungjoon Lee, Elena Newmark, Frances S. Hausmann, SaraAnn Rosenthal, Kevin Liu Kot, Yenyu Liu, William Yen, , Alberto Cruz‐Martín
This study shows that increased C4 expression in mice causes prefrontal cortex hypoconnectivity and reduced social interaction, linking C4 to schizophrenia pathogenesis.
PLoS Biology · Jan 14, 2020Peer-reviewedNeuroscience