Alberto Cruz‐Martín

Environmental risk reshapes high-confidence schizophrenia risk genes during a developmental window of vulnerability

The paper investigates how early-life stress alters the expression of schizophrenia risk genes in mice during development, identifying region- and cell-type-specific effects.

Micro- and nanoplastics alter electrophysiological brain patterns and reshape human neurodevelopmental trajectories

This study shows that micro- and nanoplastics disrupt human brain development and function by inducing inflammation, cellular senescence, and altered electrophysiological activity.

Temporal cortex astrocytic Gi-GPCR signaling regulates learned threat responses

The paper shows that Gi-GPCR signaling in temporal cortex astrocytes enhances fear memory retrieval by modulating Ca2+ transients in response to sensory cues.

Sparse Neuronal C4 Elevation Induces Network-Wide Transcriptomic and Lipid-Droplet Remodeling in the Cortical Microenvironment

This study shows that sparse neuronal C4 elevation induces broad transcriptomic and lipid-droplet remodeling in the cortical microenvironment, suggesting non-cell-autonomous effects on neighboring cells.

REVEALS: An Open Source Multi Camera GUI For Rodent Behavior Acquisition

REVEALS is an open-source GUI for rodent behavior data acquisition using multiple cameras, validated with DeepLabCut for pose estimation in behavioral assays.

Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction.

This study shows that overexpressing the schizophrenia risk gene C4 in PV cells causes sex-dependent behavioral and circuit dysfunction in mice.

C4 induces pathological synaptic loss by impairing AMPAR trafficking.

This study shows that C4 overexpression causes synaptic loss by impairing GluR1 trafficking via SNX27, independent of the complement pathway.

Distinct VIP interneurons in the cingulate cortex encode anxiogenic and social stimuli

The paper identifies distinct VIP interneuron subpopulations in the ACC that selectively encode anxiogenic, anxiolytic, social, or non-social stimuli in mice.

Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice

This study investigates sex differences in behavioral and brainstem transcriptomic changes in mice exposed to neonatal opioids, finding sex-specific neuroadaptations linked to NOWS-like behaviors.

Large-scale cellular-resolution imaging of neural activity in freely behaving mice

This paper introduces a novel miniaturized mesoscope for cellular-resolution imaging of neural activity in freely behaving mice, enabling comprehensive visualization across brain regions.

Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction

This study shows that increased C4 expression in mice causes prefrontal cortex hypoconnectivity and reduced social interaction, linking C4 to schizophrenia pathogenesis.

A Sparse Unreliable Distributed Code Underlies the Limits of Behavioral Discrimination

The paper shows that mice can perform orientation discrimination tasks quickly by integrating information from a small number of unreliable neurons in V1.

Songbird organotypic culture as an in vitro model for interrogating sparse sequencing networks

The paper develops an in vitro model using zebra finch brain slices to study sparse neuronal activity networks.