Rhushikesh A. Phadke

The paper investigates how early-life stress alters the expression of schizophrenia risk genes in mice during development, identifying region- and cell-type-specific effects.

This study shows that sparse neuronal C4 elevation induces broad transcriptomic and lipid-droplet remodeling in the cortical microenvironment, suggesting non-cell-autonomous effects on neighboring cells.

REVEALS is an open-source GUI for rodent behavior data acquisition using multiple cameras, validated with DeepLabCut for pose estimation in behavioral assays.

This study shows that overexpressing the schizophrenia risk gene C4 in PV cells causes sex-dependent behavioral and circuit dysfunction in mice.

This study shows that C4 overexpression causes synaptic loss by impairing GluR1 trafficking via SNX27, independent of the complement pathway.

The paper identifies distinct VIP interneuron subpopulations in the ACC that selectively encode anxiogenic, anxiolytic, social, or non-social stimuli in mice.

This study investigates sex differences in behavioral and brainstem transcriptomic changes in mice exposed to neonatal opioids, finding sex-specific neuroadaptations linked to NOWS-like behaviors.

This study shows that increased C4 expression in mice causes prefrontal cortex hypoconnectivity and reduced social interaction, linking C4 to schizophrenia pathogenesis.