Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection
Aaron L. Hecht, Nadim Mahmud, Subhan Chaudhry, Jacob Y. Cao, Grace Purvis Branigan, Junhee Lee, Erin Theiller, Manuela Roggiani, Elliot S. Friedman, Lindsay Herman, Bianca E. Galis, Steven M. Jones, Paul Joseph Planet, Joseph P. Zackular, David Edward Kaplan, , Gary D. Wu
This study shows lactulose consumption selects for E. coli mutations that enhance its metabolic fitness and colonization, increasing infection risk in cirrhosis patients.
bioRxiv · Mar 26, 2025 · PreprintMicrobiology