An ultra-long acting insulin enables glucose-synchronised release
Yang Zhang, Juan Zhang, Kangfan Ji, Shaoqian Mei, Su Chen, Yanfang Wang, Guangzheng Xu, Hui Zhang, Junhuan Lin, Xuehui Huang, Xiuwen Zhang, Kairui Xu, Jianchang Xu, Leihao Lu, Mowei Zhou, , Zhen Gu
This paper develops a glucose-responsive insulin analogue with ultra-long duration and glucose-synchronised release, showing prolonged normoglycaemia in diabetic mice and minipigs.
bioRxiv · Oct 12, 2025 · PreprintBioengineering