Discovering Novel Therapeutic VHHs for Emerging Viruses: Perspectives from VEEV Selection Strategies
Autumn T. LaPointe, Fortunato Ferrara, Jennifer M. Zupancic, Alba L. Montoya, Jurgen Schmidt, Li-Wei Hung, Alison M. Kell, Nileena Velappan
This paper reports four novel VHHs against VEEV E2 protein selected using computational and biochemical strategies, showing they can bind and sequester viral particles, acting as viral sponges.
Frontiers in Immunology · Mar 31, 2026Peer-reviewedImmunology