Discrete Transcriptional States Define Biphasic Immune Response and Dynamic CMS Transitions in Colorectal Cancer
Khalid Ishani, Dechen Wangmo, Atef Mir Ali, Travis J. Gates, Zejie Yan, Ava P. Gustafson, Ella Boytim, Katie Lauren Storey, Paolo Goffredo, Justin Hwang, Subbaya Subramanian
The paper uses an organoid model to identify discrete transcriptional states and immune responses in colorectal cancer, revealing hidden evolutionary patterns and CMS transitions.
bioRxiv · Feb 6, 2026 · PreprintCancer Biology