Subbaya Subramanian

Discrete Transcriptional States Define Biphasic Immune Response and Dynamic CMS Transitions in Colorectal Cancer

The paper uses an organoid model to identify discrete transcriptional states and immune responses in colorectal cancer, revealing hidden evolutionary patterns and CMS transitions.

SMAD4 Mutation Drives Gut Microbiome Shifts Toward Tumor Progression in Colorectal Cancer

This study shows that SMAD4 mutations in colorectal cancer drive microbiome changes that promote metastasis and immunosuppression.

Frequency of MicroRNA Response Elements Identifies Pathologically Relevant Signaling Pathways in Cancers

The paper identifies pathologically relevant signaling pathways in cancers by analyzing microRNA response element frequencies using a novel bioinformatics method.

Mucosal microbiota and metabolome along the intestinal tracts reveals location specific relationship

The paper analyzes mucosal microbiota and metabolome in non-human primates to identify location-specific microbial signatures and their relationship with host tissue metabolites.

RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling

The paper identifies a novel NRAS internal tandem duplication in colorectal cancer that disrupts GAP-binding, leading to sustained RAS activation and oncogenic signaling.

OMCD: OncoMir Cancer Database

OMCD provides a web-based database for pan-cancer miRNA expression analysis, enabling visualization, statistical analysis, and exploration of miRNA clusters across cancer types.

Interaction Between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer

The paper investigates the relationship between miRNA expression in CRC tissues and microbiome composition, identifying miRNAs correlated with bacterial taxa and suggesting potential therapeutic targets.