Author

Richard L. Karpel

University of Maryland, Baltimore CountyORCID 0000-0003-1891-644XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Adra Mack· 1 shared Benedikt G. H. SchoseriD· 1 shared Feng Chi WuiD· 1 shared Frank T. MartiniukiD· 1 shared Jules Guei· 1 shared Justin Martiniuk· 1 shared Kam-Meng Tchou-Wong· 1 shared Michael P. Chapman· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Adra Mack

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2 papers

Recent·Most cited

BiochemistryPLoS ONEPeer-reviewedFeb 11, 2026

Bacteriophage T4 gene 32 protein: Insights into its Interaction with ssDNA, binding cooperativity, and conformational change

Jules Guei, Michael P. Chapman, Paul N. Brothers…·Richard L. Karpel

This study investigates the interaction of bacteriophage T4 gp32 with ssDNA, binding cooperativity, and conformational changes by altering the core domain LAST sequence and truncating the protein.

DOI 10.1371/journal.pone.0332487

proteomicsexperimental assay

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GeneticsbioRxivPreprintMar 23, 2021

Crotamine as a vehicle for non-viral gene delivery for Pompe disease

Frank T. Martiniuk, Adra Mack, Justin Martiniuk…·Kam-Meng Tchou-Wong

This paper demonstrates that crotamine can deliver therapeutic genes to treat Pompe disease in vitro and in vivo, improving GAA activity and reversing clinical phenotypes.

1 citation

mouseexperimental assay

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