Sex specific axon initial segment plasticity underlies cortical hyperexcitability in trigeminal pain
Justine Loudan, Karine Hérault, Tanguy Damart, Pauline Murail, Alexanne Michon, Serine Fraiah, François Gabrielli, Xavier Moisset, Radhouane Dallel, Mickaël Zbili
This study shows that sex-specific axon initial segment plasticity increases excitability of cortical pyramidal cells in a trigeminal neuropathic pain model, contributing to hyperexcitability.
bioRxiv · Oct 11, 2025 · PreprintNeuroscience