Radhouane Dallel

This study identifies a previously dormant neuronal circuit in the spinal dorsal horn that becomes active in neuropathic pain, leading to mechanical allodynia.

This study shows nerve injury shifts spinal circuit recruitment from inhibitory to excitatory parvalbumin interneurons, causing mechanical allodynia.

This study shows that sex-specific axon initial segment plasticity increases excitability of cortical pyramidal cells in a trigeminal neuropathic pain model, contributing to hyperexcitability.

This study shows that inhibiting FLT3 signaling preserves opioid analgesia while preventing tolerance and hyperalgesia in chronic pain models.