Artificial hibernation uncovers distinct synaptic engram architecture for memory retention
Yu-Ju Lin, Ai Takahashi-Nakazato, K Tsutsumi, Taiga Takahashi, D Mercier, Hiroto Ashitomi, Ming-Ching Chiang, Matthias Georg Haberl, Marco Uytiepo, Anton Maximov, Y Makino, Tomomi Nemoto, Ryosuke Enoki, Arisa Hirano, Kohei Soga, , Kazumasa Z. Tanaka
This study uses a mouse model of artificial hibernation to show that specific synaptic engram structures are preserved despite widespread spine and synapse elimination, suggesting their role in long-term memory retention.
bioRxiv · Dec 11, 2025 · PreprintNeuroscience