Tomomi Nemoto

This paper introduces 2P-RESOLFT microscopy, achieving 205-nm lateral resolution to visualize previously unreported membrane protrusions in pancreatic beta cells.

This study uses quantum dot imaging temperature sensors to measure brain temperature in mice, revealing vascular cooling's role in protecting against heat stress in pathological conditions.

This paper introduces a data-driven correction framework to account for axial- and radial-position-dependent intensity attenuation in 3D fluorescence microscopy of C. elegans embryos, improving quantitative accuracy.

This study shows that ether phospholipids modulate mechanosensory and thermosensory responses in Drosophila by affecting PIEZO and TRPA1 channels.

This study shows that Wnt11 and core PCP components interact reciprocally to establish cell polarity in Xenopus embryos without relying on Wnt gradients.

This study uses a mouse model of artificial hibernation to show that specific synaptic engram structures are preserved despite widespread spine and synapse elimination, suggesting their role in long-term memory retention.

This study shows that body temperature, not ambient temperature, strongly regulates glucose metabolism and behavior in QIH mice, with hypometabolism being secondary to hypothermia.

This paper develops an implantable microprism interface for deep-brain imaging with submicrometer resolution and wide-field two-photon microscopy.

This study investigates how Aβ dimers alter fast and localized calcium elevations in astrocytes, finding increased frequency and occupancy of calcium events mediated by P2Y1 receptors and ER Ca2+ release.

This study examines how photothermal therapy affects ERK signaling and intercellular communication in tumor spheroids using FRET sensors and deep learning.

This study shows that SCN neurons maintain circadian rhythms at moderate hypothermia but suspend them at deep hypothermia, with Ca2+ rhythms resetting faster than transcriptional rhythms upon rewarming.

The paper develops a deep-learning-based pipeline for segmenting and tracking cells in 3D brain imaging data, achieving high accuracy across different conditions and datasets.

The paper introduces MAGICAL, an optical clearing method for in vivo fluorescence microscopy, enhancing imaging depth and resolution in living brains.