DNA Replication Modulates R-loop Levels to Maintain Genome Stability
S. Hamperl, J. C. Saldivar, M. J. Bocek, K. A. Cimprich
This study shows that DNA replication orientation affects R-loop formation, with the replisome reducing R-loops in co-directional conflicts but promoting them in head-on conflicts, leading to genome instability.
bioRxiv · Jun 26, 2017Cell Biology