Human PRPS1 filaments stabilize allosteric sites to regulate activity
K. L. Hvorecny, K. A. Hargett, J. Quispe, J. M. Kollman
This study determines structures of PRPS1 filaments in active and inhibited states, revealing how filament stability regulates enzyme activity and links to disease.
bioRxiv · Jun 27, 2022Biochemistry