Author

K. L. Hvorecny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:bacteria (other)· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. M. Kollman· 3 shared C. D. Bahl· 2 shared D. R. Madden· 2 shared N. M. Taher· 2 shared A. B. Hickman· 1 shared A. R. Halpern· 1 shared A. R. Paredez· 1 shared A. T. Heaslip· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiophysics

J. M. Kollman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa

S. He, N. M. Taher, K. L. Hvorecny, M. J. Ragusa, C. D. Bahl, A. B. Hickman, F. Dyda, D. R. Madden

This study identifies the molecular mechanisms by which CifR, an epoxide-sensing transcriptional repressor, regulates the virulence gene cif in Pseudomonas aeruginosa.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover

K. L. Hvorecny, T. E. Sladewski, E. M. De La Cruz, J. M. Kollman, A. T. Heaslip

This study investigates the dynamic properties of Toxoplasma gondii actin filaments, showing they undergo rapid disassembly and turnover due to unique biochemical features.

bioRxiv · Aug 29, 2023 · PreprintBiophysics

Human PRPS1 filaments stabilize allosteric sites to regulate activity

K. L. Hvorecny, K. A. Hargett, J. Quispe, J. M. Kollman

This study determines structures of PRPS1 filaments in active and inhibited states, revealing how filament stability regulates enzyme activity and links to disease.

bioRxiv · Jun 27, 2022Biochemistry

A second specificity-determining loop in Class A sortases: Biochemical characterization of natural sequence variation in chimeric SrtA enzymes

I. M. Piper, S. A. Struyvenberg, J. D. Valgardson, D. A. Johnson, M. Gao, K. Johnston, J. E. Svendsen, H. M. Kodama, K. L. Hvorecny, J. M. Antos, J. F. Amacher

The paper identifies a conserved loop in Class A sortases that influences substrate specificity and demonstrates how engineered chimeric enzymes can expand substrate tolerance.

bioRxiv · Mar 27, 2021Biochemistry

The Giardia lamellipodium-like ventrolateral flange supports attachment and rapid cytokinesis

W. R. Hardin, G. C. M. Alas, N. Taparia, E. B. Thomas, M. Steele-Ogus, K. L. Hvorecny, A. R. Halpern, P. Tumova, J. M. Kollman, J. C. Vaughan, N. J. Sniadecki, A. R. Paredez

This paper identifies Flangin, an actin-associated protein essential for forming the ventrolateral flange (VLF) in Giardia, which supports attachment and rapid cytokinesis.

bioRxiv · Jan 31, 2021Cell Biology

Biochemical and Structural Characterization of Two Cif-Like Epoxide Hydrolases from Burkholderia cenocepacia

N. M. Taher, K. L. Hvorecny, C. M. Burke, M. S. A. Gilman, G. E. Heussler, J. Adolf-Bryfogle, C. D. Bahl, G. A. O'Toole, D. R. Madden

This study characterizes two Cif-like epoxide hydrolases from Burkholderia cenocepacia, revealing their biochemical properties and structural differences.

bioRxiv · Jan 20, 2021Biochemistry