Author

K. A. Staines

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:development & morphogenesis· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Farquharson· 2 shared H. J. Samvelyan· 2 shared A. E. Tornqvist· 1 shared A. K. Wann· 1 shared B. Javaheri· 1 shared B. Stott· 1 shared C. Duarte· 1 shared C. E. Clarkin· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersPathology

C. Farquharson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton

L. E. Bourne, S. N. Jayash, L. V. Michels, M. Hopkinson, F. M. Guppy, C. E. Clarkin, P. Gard, N. Brissett, K. A. Staines

This study investigates the sex-specific effects of prenatal alcohol exposure on the murine skeleton, finding divergent impacts on bone formation, trabecular structure, and cortical bone parameters between male and female mice.

bioRxiv · Mar 27, 2024Cell Biology

Ciliary IFT88 safeguards coordinated epiphyseal vascularisation, resorption and ossification from disruptive physiological mechanical forces

C. R. Coveney, J. Samvelyan, J. Miotla-Zarebska, J. Carnegie, E. Chang, J. Corrin, T. Coveney, B. Stott, I. Parisi, C. Duarte, T. L. Vincent, K. A. Staines, A. K. Wann

This study shows that IFT88 in cilia protects growth plate ossification from mechanical forces by regulating vascularization and resorption in adolescent mice.

bioRxiv · Aug 6, 2021 · PreprintPhysiology

The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability

H. J. Samvelyan, C. Huesa, L. Cui Lin, C. Farquharson, K. A. Staines

This study examines whether accelerated growth due to SOCS2 deletion affects osteoarthritis vulnerability in mice, finding no effect on disease susceptibility despite changes in growth plate fusion.

bioRxiv · May 13, 2021Pathology

Proton pump inhibitors inhibit PHOSPHO1 activity and matrix mineralisation in vitro

K. A. Staines, K. Myers, K. Little, S. H. Ralston, C. Farquharson

This study shows that proton pump inhibitors inhibit PHOSPHO1 activity and bone matrix mineralisation in vitro, suggesting a mechanism for their association with fracture risk.

bioRxiv · Apr 29, 2021Cell Biology

Characterisation of growth plate dynamics in murine models of osteoarthritis

H. J. Samvelyan, K. Madi, A. E. Tornqvist, B. Javaheri, K. A. Staines

This study examines growth plate dynamics in murine osteoarthritis models, finding spatial variations in growth plate bridging linked to subchondral bone changes.

bioRxiv · Oct 14, 2020Physiology