K. Alim

Mechanotransduction in Lateral Root Initiation: A Model Integrating Growth Mechanics and Auxin Signaling

The paper proposes a model integrating growth mechanics and auxin signaling to explain lateral root initiation by showing how pericycle turgor and endodermal resistance influence auxin flow and root development.

Vascular adaptation model from force balance: Physarum polycephalum as a case study

The paper resolves a paradox in vascular adaptation by showing shear rate can drive vein dilatation through nonlinear actomyosin gel responses in Physarum polycephalum.

Network topology enables efficient response to environment in Physarum polycephalum

This study compares the avoidance response of Physarum polycephalum in I-shaped and Y-shaped forms, finding that the Y-shaped network topology allows for more efficient retraction under adverse conditions.

Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients

The paper uses patient-derived iPSC-CMs and optical biosensors to profile signaling changes in idiopathic dilated cardiomyopathy, aiming to uncover personalized disease mechanisms and therapeutic targets.

Changing flows balance nutrient absorption and bacterial growth along the gut

The paper investigates how intestinal flow velocity balances nutrient absorption and bacterial growth in mice, revealing self-regulation mechanisms.

Vein fate determined by flow-based but time-delayed integration of network architecture

The paper investigates vein dynamics in Physarum polycephalum, showing that vein fate is determined by time-delayed integration of network architecture through flow-based parameters.

Nuclei are mobile processors enabling specialization in a gigantic single-celled syncytium

This study investigates gene expression heterogeneity in the multinucleated slime mold Physarum polycephalum, showing region-specific transcriptional responses and nuclear specialization without cellular compartmentalization.

Emergence of behavior in a self-organized living matter network

This study shows how complex behaviors in slime mold emerge from self-organized actomyosin contractions, revealing a continuous spectrum of contraction modes that enable dynamic behavioral transitions.

Tissue-wide integration of mechanical cues promotes efficient auxin patterning

The paper uses a hybrid model to show that tissue-wide mechanical coupling leads to focused auxin spots through circumferential stress fields and self-reinforcing PIN polarity.