K. Khan

Mitosis exit followed by death in interphase prevents the development of polyploid giant cancer cells.

The paper identifies ST-401 as an interphase-specific killer of cancer cells that prevents the formation of polyploid giant cancer cells.

Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients

The paper uses patient-derived iPSC-CMs and optical biosensors to profile signaling changes in idiopathic dilated cardiomyopathy, aiming to uncover personalized disease mechanisms and therapeutic targets.

LC-MS/MS-PRM Quantification of IgG glycoforms using stable isotope labeled IgG1 Fc glycopeptide standard

The paper introduces a workflow for quantifying IgG glycoforms using stable isotope labeled standards and LC-MS/MS-PRM, achieving high sensitivity and precision.

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes

The paper examines the antibody response to the SARS-CoV-2 Delta variant, showing it targets class 1 and 2 epitopes more than class 3, and that mutations in these regions reduce antibody binding.

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

This study compares antibody responses to early SARS-CoV-2 isolates and the B.1.351 variant, finding shifts in immunodominance hierarchy within the spike receptor-binding domain.

SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.

Impaired T-cell and antibody immunity after COVID-19 infection in chronically immunosuppressed transplant recipients

This study evaluates T-cell and antibody immunity to SARS-CoV-2 in transplant recipients, finding impaired responses and increased CMV co-infection risk post-infection.

The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

The paper investigates the origin of HIV in the CNS of ART-suppressed individuals and finds T cell-derived HIV that can lead to drug resistance.

Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer

The paper analyzes genomic and transcriptomic data from CRC patients treated with cetuximab to identify resistance mechanisms and immune landscape changes during anti-EGFR therapy.