Cell-free chromatin particles released from dying cells inflict mitochondrial damage and ROS production in living cells
G. V. Raghuram, B. K. Tripathy, K. Avadhani, S. Shabrish, N. K. Khare, R. Lopes, K. Pal, I. Mittra
The paper shows that cell-free chromatin particles from dying cells cause mtDNA damage and ROS production in healthy cells, suggesting they are key triggers for oxidative stress-related diseases.
bioRxiv · Dec 30, 2021Biochemistry