K. Pal

High-resolution structures illuminate key principles underlying voltage and LRRC26 regulation of Slo1 channels

The paper determines high-resolution structures of Slo1 channels with mutations and LRRC26 subunits to elucidate voltage and auxiliary subunit regulation mechanisms.

Architecture and rearrangements of a sperm-specific Na+/H+ exchanger

This study determines the structure of SLC9C1, a sperm-specific Na+/H+ exchanger, revealing its tripartite organization and how it integrates voltage and cyclic nucleotide signals.

Evidence that metastases arise de novo as new cancers from cells of target organs

The paper shows that metastases form de novo in target organs when chromatin particles from dying cancer cells transform local cells into new cancers.

Macrophages form integrin-mediated adhesion rings to pinch off surface-bound objects for phagocytosis

This study shows macrophages form integrin-mediated adhesion rings to engulf surface-bound objects by local actin polymerization, not myosin II.

Cell-free chromatin particles activate immune checkpoints in human T cells: Implications for cancer therapy

The paper shows that cell-free chromatin particles activate multiple immune checkpoints in human T cells, suggesting a new approach for cancer immunotherapy.

Therapeutic interventions on human xenografts promote systemic dissemination of oncogenes

The paper shows that therapeutic interventions in human xenografts increase oncogene dissemination, which can be reduced by chromatin deactivating agents.

Tipping points in spatial ecosystems driven by correlated noise

This study examines how correlated noise affects tipping points in spatial ecosystems and evaluates early warning indicators for detecting these transitions.

Cell-free chromatin particles released from dying cells inflict mitochondrial damage and ROS production in living cells

The paper shows that cell-free chromatin particles from dying cells cause mtDNA damage and ROS production in healthy cells, suggesting they are key triggers for oxidative stress-related diseases.

Fluorogenic DNase Sensor Reveals Ubiquitous DNase Activity in Podosomes and Invadopodia

The paper identifies DNase activity in invadosomes across cell types and species, revealing DNase X as the recruited enzyme that degrades extracellular DNA.

A complex structure of arrestin-2 bound to a G protein-coupled receptor

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

Health behaviors among male and female university students in Cambodia: a cross-sectional survey

This study surveys health behaviors of Cambodian university students, finding low substance use and sexual risk behaviors but concerning levels of physical inactivity and poor diet.

Cellular metabolic activity marker via selective turn-ON detection of serum albumin using an NBD-based fluoroprobe

The paper develops a fluoroprobe (NBD-Bu) that selectively detects serum albumin to assess cellular metabolic activity in cancer and normal cells, showing fluorescence enhancement and validated through microscopy.