I. Mittra

Horizontally transferred cell-free chromatin particles function as autonomous satellite genomes and vehicles for transposable elements within host cells

Evidence that metastases arise de novo as new cancers from cells of target organs

The paper shows that metastases form de novo in target organs when chromatin particles from dying cancer cells transform local cells into new cancers.

Cell-free chromatin particles from dying cells promote the induction of an immune response in human lymphocytes

The paper shows that cell-free chromatin particles from dying cells trigger immune responses in human lymphocytes via the cGAS-STING pathway.

Cell-free chromatin particles activate immune checkpoints in human T cells: Implications for cancer therapy

The paper shows that cell-free chromatin particles activate multiple immune checkpoints in human T cells, suggesting a new approach for cancer immunotherapy.

Therapeutic interventions on human xenografts promote systemic dissemination of oncogenes

The paper shows that therapeutic interventions in human xenografts increase oncogene dissemination, which can be reduced by chromatin deactivating agents.

Cell-free chromatin particles released from dying cells inflict mitochondrial damage and ROS production in living cells

The paper shows that cell-free chromatin particles from dying cells cause mtDNA damage and ROS production in healthy cells, suggesting they are key triggers for oxidative stress-related diseases.

Structural and energetic profiling of SARS-CoV-2 antibody recognition and the impact of circulating variants

The paper maps antibody recognition of SARS-CoV-2 spike RBD using computational structural analysis and identifies antibodies effective against viral variants.