Author

K. Barakat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Barr· 1 shared A. Chattopadhyay· 1 shared A. G. Edwards· 1 shared B. E. Gruber· 1 shared I. Arab· 1 shared K. Chen· 1 shared K. Egghe· 1 shared K. Laukens· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Barr

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Author profile →

3 papers

Recent·Most cited

The Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin Inhibits Long QT 3 Late Sodium Currents in a Mutation Specific Manner

L. Lunsonga, M. Fatehi, W. Long, A. Barr, B. E. Gruber, A. Chattopadhyay, K. Barakat, A. G. Edwards, P. E. Light

This paper investigates how empagliflozin affects late sodium currents in specific LQT3 mutations, finding it selectively inhibits these currents in some mutations but not others.

bioRxiv · Apr 15, 2024Pharmacology & Toxicology

Benchmarking of Small Molecule Feature Representations for hERG, Nav1.5, and Cav1.2 Cardiotoxicity Prediction

I. Arab, K. Egghe, K. Laukens, K. Chen, K. Barakat, W. Bittremieux

This paper benchmarks small molecule feature representations for predicting cardiotoxicity against hERG, Nav1.5, and Cav1.2 channels using a new dataset and tool.

bioRxiv · Aug 15, 2023Pharmacology & Toxicology

A Deep Dive into the SARS-Cov-2 Polymerase Assembly: Identifying Novel Allosteric Sites and Analyzing the Hydrogen Bond Networks and Correlated Dynamics

K. Barakat, M. Ahmed, Y. Tabana, M. Ha

This paper analyzes the SARS-CoV-2 polymerase structure and dynamics to identify novel allosteric sites and hydrogen bond networks, suggesting potential targets for antiviral drugs.

Journal of Biomolecular Structure and Dynamics · Nov 26, 2022Peer-reviewedBiophysics