Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
A. C. Cannon, K. Budagyan, C. Uribe-Alvarez, A. M. Kurimchak, D. Araiza-Olivera, K. Q. Cai, S. Peri, Y. Zhou, J. S. Duncan, J. Chernoff
This study identifies CDK9 as a novel therapeutic target in RAC1P29S-mutant melanoma and shows that combining CDK9 inhibition with anti-PD-1 therapy enhances tumor suppression.
bioRxiv · Jun 27, 2023 · PreprintCancer Biology