J. Chernoff

Identifying and targeting key driver genes for collagen production within the 11q13/14 breast cancer amplicon

This study identifies P4HA3 and SERPINH1 as key driver genes for collagen production in IntClust-2 breast cancer, showing their role in cell viability, proliferation, and migration, and demonstrates that targeting these genes can reduce tumor growth.

Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

This study identifies CDK9 as a novel therapeutic target in RAC1P29S-mutant melanoma and shows that combining CDK9 inhibition with anti-PD-1 therapy enhances tumor suppression.

A PTP1B-Cdk3 signaling axis promotes cell cycle progression of human glioblastoma cells through an Rb-E2F dependent pathway

This study identifies a PTP1B-Cdk3 signaling axis that promotes glioblastoma cell cycle progression via Rb-E2F pathway, showing PTP1B dephosphorylates Cdk3 and inhibits its activity.

Development and utility of a PAK1-selective degrader

This study develops a PAK1-selective degrader, BJG-05-039, which shows enhanced anti-proliferative effects compared to the parent inhibitor NVS-PAK1-1 in PAK1-dependent cell lines.

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Malignant Mesothelioma

This study shows that inactivating Pak2 reduces tumor development in Nf2-deficient mice, suggesting PAK inhibition could be a therapeutic strategy for NF2-deficient cancers.

Targeting effector pathways in RAC1P29S-driven malignant melanoma

This study investigates the efficacy of targeting effector pathways of RAC1P29S in melanoma, showing that PAK and SRF/MRTF inhibitors reduce tumor growth in vitro and in zebrafish models.