Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive EV-A71 virulence in mice
H. K. Tee, C. W. Tan, T. Yogarajah, M. H. P. Lee, H. J. Chai, N. A. Hanapi, S. R. Yusof, K. C. Ong, V. S. Lee, I.-C. Sam, Y. F. Chan
This study shows that electrostatic interactions at the five-fold axis of EV-A71 influence heparin-binding and drive virulence in mice by altering viremia and neuroinvasion.
bioRxiv · May 23, 2019Microbiology