H. K. Tee

Enterovirus A71 adaptation to heparan sulfate comes with capsid stability tradeoff

This study shows that EV-A71 adapts to heparan sulfate by losing pH-dependent uncoating, which compromises capsid stability and affects viral fitness in vivo.

Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive EV-A71 virulence in mice

This study shows that electrostatic interactions at the five-fold axis of EV-A71 influence heparin-binding and drive virulence in mice by altering viremia and neuroinvasion.