Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch
C. W. Hicks, S. Rahman, S. L. Gloor, J. K. Fields, N. L. Husby, A. Vaidya, K. E. Maier, M. Morgan, M.-C. Keogh, C. Wolberger
This study reveals that H2BK120ub blocks the nucleosome acidic patch, preventing protein binding, while H2AK119ub does not, highlighting distinct roles of these ubiquitinations in chromatin regulation.
bioRxiv · Feb 22, 2024Biophysics