Author

M.-C. Keogh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:chromatin & epigenetic regulation· 6 Assay:ChIP-seq· 4 Organism:human· 4 Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. A. Cheek· 4 shared M. J. Meiners· 4 shared M. R. Marunde· 3 shared S. A. Howard· 3 shared A. Shilatifard· 2 shared A. Vaidya· 2 shared I. K. Popova· 2 shared J. M. Burg· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersBiochemistry

M. A. Cheek

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Author profile →

8 papers

Recent·Most cited

Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch

C. W. Hicks, S. Rahman, S. L. Gloor, J. K. Fields, N. L. Husby, A. Vaidya, K. E. Maier, M. Morgan, M.-C. Keogh, C. Wolberger

This study reveals that H2BK120ub blocks the nucleosome acidic patch, preventing protein binding, while H2AK119ub does not, highlighting distinct roles of these ubiquitinations in chromatin regulation.

bioRxiv · Feb 22, 2024Biophysics

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

K. Jain, M. R. Marunde, J. M. Burg, S. L. Gloor, F. M. Joseph, K. F. Poncha, Z. B. Gillespie, K. L. Rodriguez, I. K. Popova, N. W. Hall, A. Vaidya, S. A. Howard, H. F. Taylor, L. Mukhsinova, U. C. Onuoha, , B. D. Strahl

The paper shows that H3 tail acetylation enhances accessibility of both H3K4 methyl readers and writers, revealing an acetylation-mediated chromatin switch that modulates H3K4 methylation read-write capability.

bioRxiv · Feb 28, 2022Biochemistry

Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division

H. E. Opalko, K. E. Miller, H.-S. Kim, C. A. Vargas-Garcia, A. Singh, M.-C. Keogh, J. B. Moseley

This study identifies Arf6 as an anchor for Cdr2 nodes at the cell cortex, essential for surface area-based size control in fission yeast.

bioRxiv · Aug 17, 2021Cell Biology

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

D. Dilworth, R. P. Hanley, R. Ferreira de Freitas, A. Allali-Hassani, M. Zhou, N. Mehta, M. R. Marunde, S. Ackloo, E. Marcon, F. Li, I. Chau, A. Bolotokova, S. Qin, M. Lei, Y. Liu, , M. Schapira

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

bioRxiv · Mar 5, 2021 · PreprintCell Biology

Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis - Top-Down Mass Spectrometry (nCZE-TDMS)

K. Jooss, L. F. Schachner, R. Watson, Z. B. Gillespie, S. A. Howard, M. A. Cheek, M. J. Meiners, J. D. Licht, M.-C. Keogh, N. L. Kelleher

The paper introduces nCZE-TDMS, a platform for separating and characterizing nucleosomes, histone subunits, and PTMs, and applies it to study histone modifications in cell lines with altered NSD2/MMSET expression.

bioRxiv · Nov 25, 2020Biochemistry

Decoding the Protein Composition of Whole Nucleosomes with Nuc-MS

L. F. Schachner, K. Jooss, M. A. Morgan, A. Piunti, M. J. Meiners, A. Lee, J. O. Kafader, M. Iwanaszko, M. A. Cheek, J. M. Burg, S. A. Howard, M.-C. Keogh, A. Shilatifard, N. L. Kelleher

The paper introduces Nuc-MS, a method to analyze protein composition of whole nucleosomes, revealing specific histone variants and modifications associated with oncogenic states.

bioRxiv · Sep 8, 2020Biochemistry

A ChIP-exo screen of 887 PCRP transcription factor antibodies in human cells

W. K. Lai, L. Mariani, G. Rothschild, E. R. Smith, B. J. Venters, T. R. Blanda, P. K. Kuntala, K. Bocklund, J. Mairose, S. N. Dweikat, K. Mistretta, M. J. Rossi, D. James, J. T. Anderson, S. K. Phanor, , B. F. Pugh

The paper evaluates 887 PCRP antibodies against human transcription factors using ChIP-exo and other assays, identifying 5% as strong candidates and 34% as warranting further testing.

bioRxiv · Jun 8, 2020Biochemistry

Structural insights into the recognition of mono- and di-acetylated histones by the ATAD2B bromodomain

J. T. Lloyd, K. McLaughlin, M. Y. Lubula, J. C. Gay, A. Dest, C. Gao, M. Phillips, M. Tonelli, G. Cornilescu, M. R. Marunde, C. M. Evans, S. P. Boyson, S. Carlson, M.-C. Keogh, J. L. Markley, , K. C. Glass

This study investigates the ligand specificity of the ATAD2B bromodomain, showing it binds mono- and di-acetylated histones and identifies structural features critical for this recognition.

bioRxiv · May 12, 2020 · PreprintBiochemistry