Author

C. Wolberger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Biochemistry· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:chromatin & epigenetic regulation· 10 Assay:structural biology· 4 Organism:yeast· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

S. Rahman· 3 shared C. Hicks· 2 shared E. J. Worden· 2 shared L. T. Que· 2 shared M. E. Morrow· 2 shared M. Nune· 2 shared M. T. Morgan· 2 shared N. Hoffmann· 2 shared

Activity by Year

2018-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersBiophysics

S. Rahman

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Author profile →

12 papers

Recent·Most cited

FACT frees Ubp10 from nucleosome sequestration after rapid H2B deubiquitination

R. Merino-Urteaga, J. Zaehringer, M. Nune, C. Wolberger, Taekjip Ha

The paper shows that FACT facilitates Ubp10 release from nucleosomes after H2B deubiquitination, revealing release as the rate-limiting step for Ubp10 turnover.

bioRxiv · Nov 9, 2026 · PreprintBiophysics

Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch

C. W. Hicks, S. Rahman, S. L. Gloor, J. K. Fields, N. L. Husby, A. Vaidya, K. E. Maier, M. Morgan, M.-C. Keogh, C. Wolberger

This study reveals that H2BK120ub blocks the nucleosome acidic patch, preventing protein binding, while H2AK119ub does not, highlighting distinct roles of these ubiquitinations in chromatin regulation.

bioRxiv · Feb 22, 2024Biophysics

Mechanism of histone H2B monoubiquitination by Bre1

F. Zhao, C. Hicks, C. Wolberger

The paper reveals the mechanism by which Bre1 monoubiquitinates histone H2B, showing how its RING domains position Rad6 and contact DNA, and suggests a general mechanism for histone specificity.

bioRxiv · Mar 27, 2023Biophysics

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

S. T. Haile, S. Rahman, B. Orsburn, N. N. Bumpus, C. Wolberger

This study shows the SWIRM domain of Ada2 tethers the HAT module to SAGA, modulating its deubiquitinating activity.

bioRxiv · Dec 29, 2022Biochemistry

Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome

N. Hoffmann, S. Rahman, E. J. Worden, M. L. Smith, K. E. Namitz, B. Knutson, M. S. Cosgrove, C. Wolberger

The paper determines structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosomes using cryo-EM and mass spectrometry-crosslinking, revealing multiple states and the role of ubiquitin in complex assembly.

bioRxiv · Apr 4, 2022 · PreprintBiophysics

The ASCC2 CUE domain contacts adjacent ubiquitins to recognize K63-linked polyubiquitin

P. M. Lombardi, S. Haile, T. Rusanov, R. Rodell, R. Anoh, J. G. Baer, K. A. Burke, L. N. Gray, A. R. Hacker, K. R. Kebreau, C. K. Ngandu, H. A. Orland, E. Osei-Asante, D. P. Schmelyun, D. E. Shorb, , C. Wolberger

This study shows that the ASCC2 CUE domain binds K63-linked diubiquitin by interacting with both ubiquitins, with unique contacts to the proximal ubiquitin that are critical for ASCC2 recruitment during DNA alkylation response.

bioRxiv · Oct 17, 2021 · PreprintBiophysics

Potent macrocycle inhibitors of the human SAGA deubiquitinating module

M. T. Morgan, T. Ikenoue, H. Suga, C. Wolberger

The paper identifies potent cyclic peptide inhibitors of the USP22 subunit in the SAGA DUB module, showing increased H2B monoubiquitination in treated cells.

bioRxiv · May 13, 2021Biochemistry

Measuring DNA mechanics on the genome scale

A. Basu, D. G. Bobrovnikov, Z. Qureshi, T. Kayikcioglu, T. T. Ngo, A. Ranjan, S. Eustermann, B. Cieza, M. Hejna, T. H. Rube, K.-P. Hopfner, C. Wolberger, J. S. Song, T. Ha

This paper develops loop-seq to measure DNA bendability genome-wide and finds sequence-encoded low bendability upstream of TSSs that influences nucleosome positioning and chromatin remodeling.

bioRxiv · Aug 17, 2020Biophysics

Characterization of OTUB1 activation and inhibition by different E2 enzymes

L. T. Que, M. E. Morrow, C. Wolberger

This study characterizes how OTUB1 interacts with different E2 enzymes, showing both stimulatory and inhibitory effects under physiological conditions.

bioRxiv · Nov 20, 2019 · PreprintBiochemistry

The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1L

E. J. Worden, N. Hoffmann, C. Hicks, C. Wolberger

This study reveals how H2B ubiquitination enables Dot1L to methylate H3K79 by inducing a conformational change in histone H3.

bioRxiv · Dec 22, 2018Biochemistry

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

M. Nune, M. T. Morgan, Z. Connell, L. McCullough, M. Jbara, H. Sun, A. Brik, T. Formosa, C. Wolberger

bioRxiv · Aug 22, 2018Biochemistry

OTUB1 non-catalytically regulates the stability of the E2 ubiquitin conjugating enzyme UBE2E1

N. Pasupala, M. E. Morrow, L. T. Que, B. A. Malynn, A. Ma, C. Wolberger

This study identifies a non-catalytic role of OTUB1 in stabilizing the E2 ubiquitin conjugating enzyme UBE2E1 by preventing its autoubiquitination and proteasomal degradation.

bioRxiv · Jun 29, 2018Cell Biology