Elucidating effects of single and multiple resistance mechanisms on bacterial response to meropenem by quantitative and systems pharmacology modeling and population genomics
D. T. Fuhs, S. Cortes-Lara, J. R. Tait, K. E. Rogers, C. Lopez-Causape, W. L. Lee, D. M. Shackleford, R. L. Nation, A. Oliver, C. B. Landersdorfer
This study uses QSP modeling and population genomics to show that baseline resistance mechanisms in Pseudomonas aeruginosa affect bacterial killing and resistance emergence, and that fT>MIC cannot predict these outcomes.
bioRxiv · Feb 17, 2024 · PreprintMicrobiology