A. Oliver

Involvement of Pf-like phages in resistance to phage infection in clinical isolates of P. aeruginosa from cystic fibrosis patients

The paper identifies 12 new Pf-like phages in P. aeruginosa clinical isolates and links their presence to resistance against phage infection through novel anti-phage defence systems.

Elucidating effects of single and multiple resistance mechanisms on bacterial response to meropenem by quantitative and systems pharmacology modeling and population genomics

This study uses QSP modeling and population genomics to show that baseline resistance mechanisms in Pseudomonas aeruginosa affect bacterial killing and resistance emergence, and that fT>MIC cannot predict these outcomes.

Enrichable consortia of microbial symbionts degrade macroalgal polysaccharides in Kyphosus fish

This study identifies microbial symbionts in Kyphosus fish that collaboratively degrade macroalgal polysaccharides through genomic analysis and suggests their potential for industrial applications.

Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade the respiratory microbiome

This study shows antibiotic resistance in Pseudomonas aeruginosa can both help and hinder its ability to invade respiratory microbiomes, depending on the commensal microbes involved.

Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction

The paper determines the structure of the human RAD17-RFC clamp loader complex bound to 9-1-1 and a dsDNA-ssDNA junction, explaining specificity and orientation mechanisms.

Phenotypic and transcriptional response of Daphnia pulicaria to the combined effects of temperature and predation

This study examines how temperature and fish predation affect Daphnia pulicaria's physiology and gene expression, finding synergistic interactions between these stressors.

Polyclonal pathogen populations accelerate the evolution of antibiotic resistance in patients

Antibiotic resistance evolves quickly in patients colonized by polyclonal pathogen populations.

Whole genome sequencing evidences higher rates of relapse in Clostridioides difficile infection caused by PCR ribotype 106

This study uses whole genome sequencing to show that recurrent Clostridioides difficile infections caused by ribotype 106 are mainly due to relapses from the same strain rather than reinfections.

Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex

This study identifies Nse5/6 as a negative regulator of Smc5/6 ATPase activity in S. cerevisiae by showing it suppresses ATP turnover through binding to the complex head-end.

High fiber, whole foods dietary intervention alters the human gut microbiome but not fecal short-chain fatty acids

A two-week high-fiber diet intervention increased gut microbiome diversity and specific fiber-degrading bacteria but did not significantly alter fecal short-chain fatty acid levels.

Comparing Fecal, Saliva, and Chicha Microbiomes Between Mothers and Children in an Indigenous Ecuadorian Cohort

The paper compares microbiomes in fecal, saliva, and chicha samples from mothers and children in an indigenous Ecuadorian cohort, finding household effects on microbiome composition but no significant differences between mothers and offspring.

Rapid evolution drives the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

The paper tracks the rapid evolution of carbapenem resistance in P. aeruginosa during an acute infection, showing resistance rise and fall due to antibiotic treatment.

In vitro and in vivo efficacy of the combination of colistin and endolysins against clinical strains of Multi-Drug Resistant (MDR) pathogens

This study evaluates the in vitro and in vivo efficacy of combining colistin with endolysins ElyA1 and ElyA2 against MDR pathogens, finding that ElyA1 enhances colistin's antimicrobial activity and reduces its MIC.

Evaluating rehabilitation progress using motion features identified by machine learning

This paper uses machine learning to identify motion features for evaluating rehabilitation progress in stroke patients, finding that movement smoothness is the best measure.

Cervicovaginal microbiome composition drives metabolic profiles in healthy pregnancy

The paper investigates how cervicovaginal microbiome composition influences metabolic profiles in healthy pregnancies across trimesters and the first year of life.

Fighting antimicrobial resistance in Pseudomonas aeruginosa with machine learning-enabled molecular diagnostics

This study uses machine learning on genomic and transcriptomic data to predict antimicrobial resistance in Pseudomonas aeruginosa, achieving high sensitivity for four antibiotics.

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

This study identifies a phosphorylation-dependent interaction between 53BP1 and TOPBP1 that is critical for the G1 DNA damage checkpoint by recruiting ATR and CHK1 to damage foci.

N-terminal BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

The paper defines the specificity of N-terminal BRCT domains in TOPBP1/Rad4 for phosphopeptide ligands through structural and biochemical analysis of their interactions with various proteins.