N-acetylaspartate improves cell survival when glucose is limiting
H. F. Alkan, K. E. Walter, H. Hackl, M. Vander Heiden, T. Madl, J. Bogner-Strauss
The paper shows N-acetylaspartate (NAA) supports cell survival in low-glucose conditions by maintaining UDP-GlcNAc levels and reducing ER stress, independent of its breakdown into aspartate or acetate.
bioRxiv · May 28, 2020 · PreprintCancer Biology