2'-O-methylation alters the RNA secondary structural ensemble
H. Abou Assi, H. Shi, B. Liu, M. C. Clay, K. Erharter, C. Kreutz, C. Holley, H. Al-Hashimi
This study shows that 2'-O-methylation stabilizes alternative RNA secondary structures and increases the lifetime of excited states in the HIV-1 TAR element.
bioRxiv · May 28, 2020 · PreprintBiochemistry