Author

H. Al-Hashimi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Liu· 3 shared C. Kreutz· 2 shared H. Shi· 2 shared A. K. Rangadurai· 1 shared A. Manghrani· 1 shared C. Holley· 1 shared C.-c. Chu· 1 shared H. Abou Assi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

B. Liu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: Implications for the fidelity of transcription and CRISPR/Cas9 gene editing

O. Szekely, A. K. Rangadurai, S. Gu, A. Manghrani, S. Guseva, H. Al-Hashimi

This study uses NMR to show that G*T/U mismatches in RNA:DNA hybrids can form Watson-Crick-like conformations, potentially contributing to transcription errors and CRISPR/Cas9 off-target effects.

bioRxiv · Aug 24, 2023Biophysics

Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA

H. Shi, I. Kimsey, H.-F. Liu, U. Pham, M. Schumacher, H. Al-Hashimi

The paper identifies seventeen Hoogsteen base pairs in protein-bound DNA, seven of which are novel, and suggests their role in DNA repair and genomic stress.

bioRxiv · Jun 5, 2021Biophysics

2'-O-methylation alters the RNA secondary structural ensemble

H. Abou Assi, H. Shi, B. Liu, M. C. Clay, K. Erharter, C. Kreutz, C. Holley, H. Al-Hashimi

This study shows that 2'-O-methylation stabilizes alternative RNA secondary structures and increases the lifetime of excited states in the HIV-1 TAR element.

bioRxiv · May 28, 2020 · PreprintBiochemistry

Anomalous reverse transcription through chemical modifications in polyadenosine stretches

W. Kladwang, V. V. Topkar, B. Liu, T. Hodges, S. Keane, H. Al-Hashimi, R. Das

The paper re-analyzes data on reverse transcriptase behavior at chemically modified polyadenosine stretches, finding near-quantitative bypass of modifications.

bioRxiv · Jan 7, 2020Biochemistry

m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB

C.-c. Chu, B. Liu, R. Plangger, C. Kreutz, H. Al-Hashimi

This study shows that m6A modification in HIV-1 RRE stem IIB has minimal effects on structure, dynamics, and Rev ARM binding.

bioRxiv · Oct 24, 2019Biochemistry