Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human monocyte-derived macrophages and blunt glycolysis in response to antigenic stimuli.
G. Leisching, A. Yennemadi, K. Gogan, J. Keane
This study examines how chronic exposure to type I interferons affects macrophage metabolism, revealing distinct metabolic profiles and functional changes in response to antigenic stimuli.
bioRxiv · Dec 16, 2023 · PreprintImmunology