Author

J. Keane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Yennemadi· 2 shared G. Leisching· 2 shared A. A. Brugman· 1 shared A. V. Protasio· 1 shared A. Wangwiwatsin· 1 shared C. De Pasquale· 1 shared C. O. Maoldomhnaigh· 1 shared C. Owusu· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

A. Yennemadi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis dependent functional plasticity.

D. J. Cox, S. A. Connolly, C. O. Maoldomhnaigh, A. A. Brugman, O. S. Thomas, E. Duffin, K. M. Gogan, O. O Gallchobhair, D. M. Murphy, S. A. O'Rourke, F. O'Connell, P. Nadarajan, J. J. Phelan, L. E. Gleeson, S. A. Basdeo, J. Keane

This study shows that human airway macrophages reprogram their metabolism in response to IFN-γ, leading to glycolysis-dependent functional plasticity that differs from monocyte-derived macrophages.

bioRxiv · Mar 20, 2024Immunology

Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human monocyte-derived macrophages and blunt glycolysis in response to antigenic stimuli.

G. Leisching, A. Yennemadi, K. Gogan, J. Keane

This study examines how chronic exposure to type I interferons affects macrophage metabolism, revealing distinct metabolic profiles and functional changes in response to antigenic stimuli.

bioRxiv · Dec 16, 2023 · PreprintImmunology

Chronic IFNα treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring

G. Leisching, A. Yennemadi, J. Keane, C. De Pasquale, M. Bianchi, M. Glass, G. Jameson

This study shows that chronic IFNα treatment in rats causes hypermetabolic immune cells, increased plasma succinate, and impaired bacterial response.

bioRxiv · Oct 17, 2022Immunology

Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development

M. Berriman, A. Wangwiwatsin, A. V. Protasio, S. Wilson, C. Owusu, N. Holroyd, M. Sanders, J. Keane, M. Doenhoff, G. Rinaldi

This study analyzes RNA-seq data from Schistosoma mansoni during intra-mammalian development, identifying genes involved in immune evasion and adaptation to oxidative stress.

PLOS Neglected Tropical Diseases · May 6, 2020Peer-reviewedMicrobiology